This editorial article introduces the structure and content of articles accepted for presentation at the Fourth International Scientific Conference “Digital Transformation, Cyber Security and Resilience, DIGILIENCE 2022. The volume includes articles presenting results on six particular topics: Advanced Threat Intelligence and Information Sharing; Digitalization and Privacy Preservation; Governing Cybersecurity Networks and Ecosystems; Developing Critical Cyber Skills; Human Factors for Safety and Resilience to Cyber/Hybrid Influence; and Cyber Ranges, Simulation and Training.