This article elaborates on four emerging research topics, considered of key importance for the understanding of and finding effective countermeasures to hybrid threats: (1) exploring the interlinked dynamics of a conflict developing in parallel in the physical world and on social networks; (2) analysing the expanding involvement of private actors who serve as proxies for an assertive state; (3) exploring the vulnerabilities of national security systems to hybrid influence and finding effective countermeasures; and (4) designing an architecture that allows to study the problem of hybrid threats holistically by providing interoperability among domain-specific or cross-domain models, or ‘use cases,’ and the respective data. All these require multi- and interdisciplinary research and consistent accumulation, verification and sharing of data, case studies and models.