This paper presents results from the analysis of methodologies and standards aiming to meet the requirements to security management of enterprises implementing Industry 4.0 principles. Key standards such as ISO/IEC 7498, 15408, 18045, 20000, 27000 have been analysed to suggest an approach to the development of integrated security and safety management system structure considering threats of intrusion into physical, information and signal spaces. This system, based on the cybernetic principles of control, is part of the enterprise management system. Security subsystems check and control according to individual and general objectives for physical, information and signal spaces and respective requirements-based models. On that basis the paper presents results and recommendations for enhancing and implementing integrated security management systems.