Inter-organizational cooperation at both national and international level depends on many factors. Some can have negative influence and be perceived as obstacles to efficient inter-organizational cooperation. Obstacles could be caused by bureaucratic rivalries, parochial mentality, rigid organizational rules and procedures, inappropriate information, harmful leadership, etc. Due to a variety of hybrid threats, the logical response of states’ leaders should be directed to gathering information from all available sources in order to become resilient and respond adequately to hybrid threats. Identification of obstacles and evaluation of their influence may contribute to the ability to resolve problems, to avoid obstacles or, at least, to clarify needs and opportunities for improvement.