In order to more effectively analyze strategic, force structure, and systems choices associated with the national security environment of the 21st Century, the US Department of Defense is attempting to improve its approach to the development, management and application of Modeling and Simulation (M&S). It has established a new structure to oversee and integrate M&S activity and directed DoD communities to develop internal business plans to focus that effort. The Analysis Community has responded by identifying desired analytic M&S goals, measuring current capabilities, prioritizing capability gaps, and then outlining potential solutions. These activities are being captured as part of an analysis M&S business plan product and process. This paper notes that a key desired outcome is improved M&S to address three areas of particular concern: Irregular Warfare and the Global War on Terror; Stability, Security, Transition and Reconstruction operations; and Joint, Interagency, and Multinational operations. In these areas, the Department is seeking a broad, collaborative approach to engage interagency and allied partners in developing and using new analytic approaches and tools.