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In an environment of technological revolution, C4ISR (command, control, communications, computers, intelligence, surveillance and reconnaissance) systems are given priority in force modernization. On the other side, the modernization of C4ISR, especially when implemented in interagency and international cooperation, may be an important facilitator for the overall defense and security sector reform. The focus of this article is on definition of the priority programs, model of life cycle support of C4ISR systems and its organizational dimension. We propose one possible strategy for C4ISR development in Bulgaria and South-East Europe. Organizational issues and initiatives, such as the establishment of C4 Regional Coordination Group are also debated.